Table 2 Risks of subsequent major mental disorders between the offspring of parents with or without migraine, stratified by fathers and mothers â€
From: Risk of major mental disorders in the offspring of parents with migraine
| Â | ASD | ADHD | Schizophrenia | Bipolar disorder | Depressive disorder |
|---|---|---|---|---|---|
| Â | All offspring sample | ||||
Offspring of fathers without migraine (reference, n, %) | 181 (0.3) | 1113 (1.7) | 176 (0.3) | 158 (0.2) | 844 (1.3) |
Offspring of fathers with migraine (n, %) | 22 (0.3) | 134 (2.1) | 19 (0.3) | 22 (0.3) | 83 (1.3) |
 HR (95% CI) | 1.20 (0.77–1.87) | 1.18 (0.99–1.42) | 1.00 (0.62–1.61) | 1.22 (0.78–1.92) | 0.94 (0.75–1.18) |
Offspring of mothers without migraine (reference, n, %) | 470 (0.3) | 2689 (1.6) | 477 (0.3) | 374 (0.2) | 2347 (1.4) |
Offspring of mothers with migraine (n, %) | 49 (0.3) | 408 (2.5) | 52 (0.3) | 59 (0.4) | 373 (2.3) |
 HR (95% CI) | 1.00 (0.74–1.34) | 1.43 (1.29–1.59) | 1.01 (0.75–1.34) | 1.41 (1.07–1.87) | 1.46 (1.31–1.63) |
| Â | Male offspring sample | ||||
Offspring of fathers without migraine (reference, n, %) | 152 (0.5) | 904 (3.7) | 92 (0.3) | 80 (0.2) | 376 (1.1) |
Offspring of fathers with migraine (n, %) | 18 (0.5) | 105 (3.1) | 12 (0.4) | 13 (0.4) | 35 (1.0) |
 HR (95% CI) | 1.15 (0.70–1.87) | 1.14 (0.93–1.40) | 1.21 (0.66–2.21) | 1.47 (0.81–2.65) | 0.86 (0.61–1.22) |
Offspring of mothers without migraine (reference, n, %) | 394 (0.5) | 2149 (2.5) | 253 (0.3) | 170 (0.2) | 968 (1.1) |
Offspring of mothers with migraine (n, %) | 41 (0.5) | 316 (3.7) | 27 (0.3) | 21 (0.2) | 162 (1.9) |
 HR (95% CI) | 0.99 (0.71–1.36) | 1.40 (1.25–1.58) | 0.99 (0.67–1.48) | 1.05 (0.66–1.66) | 1.56 (1.32–1.85) |
| Â | Female offspring sample | ||||
Offspring of fathers without migraine (reference, n, %) | 29 (0.1) | 209 (0.7) | 84 (0.3) | 78 (0.3) | 468 (1.6) |
Offspring of fathers with migraine (n, %) | 4 (0.1) | 29 (1.0) | 7 (0.2) | 9 (0.3) | 48 (1.6) |
 HR (95% CI) | 1.30 (0.46–3.72) | 1.33 (0.90–1.97) | 0.82 (0.38–1.78) | 1.05 (0.53–2.11) | 1.00 (0.74–1.35) |
Offspring of mothers without migraine (reference, n, %) | 76 (0.1) | 540 (0.7) | 224 (0.3) | 204 (0.3) | 1379 (1.8) |
Offspring of mothers with migraine (n, %) | 8 (0.1) | 92 (1.2) | 25 (0.3) | 38 (0.5) | 211 (2.7) |
 HR (95% CI) | 1.03 (0.50–2.14) | 1.61 (1.29–2.01) | 1.00 (0.66–1.52) | 1.68 (1.19–2.39) | 1.40 (1.21–1.62) |