Table 1 Sertraline clinical studies considered for the pooled analysis
From: A pooled analysis of the efficacy of sertraline in women, with a focus on those of childbearing age
Serial number | Study number | Dose design | Participant characteristics (Only sertraline and placebo arms) | Treatment arms | Duration | Efficacy parameter | |
|---|---|---|---|---|---|---|---|
All randomized (n) | Full analysis set females (n) | ||||||
1 | 103 | Fixed dose | 369 | 197 | Sertraline, Placebo | 6 weeks | HAMD-17, CGI |
2 | 104 | Dose titration | 299 | 157 | Sertraline, Amitriptyline, Placebo | 8 weeks | HAMD-17, CGI |
3 | 105 | Fixed dose | 161 | 80 | Sertraline, Amitriptyline, | 8 weeks | HAMD-17, CGI |
4 | 111 | Dose titration | 220 | 154 | Sertraline, Fluoxetine, Placebo | 8 weeks | HAMD-17, CGI |
5 | 116 | Dose titration | 28 | 12 | Sertraline, Desipramine, Placebo | 8 weeks | HAMD-17 |
6 | 315 | Dose titration | 165 | 118 | Sertraline, Amitriptyline, Placebo | 8 weeks | HAMD-17, CGI |
7 | NY89002 | Dose titration | 142 | 82 | Sertraline, Fluoxetine | 6 Weeks | HAMD-17 |
8 | R0167 | Dose titration | 261 | 171 | Sertraline, Amitriptyline, Placebo | 8 weeks | HAMD-17, CGI |
9 | UK-88-001B | Dose titration | 187 | 126 | Sertraline, Dothiepin, Placebo | 6 Weeks | CGI |