Fig. 2

Sample selection. ^aContinuous clinical activity is defined as consecutive quarters with ≥ 1 pharmacy, medical, or hospital claim. ^bSee Supplemental Table 4 for list of HCPCS codes for antipsychotic LAIs. ^cSee Supplemental Table 3 for list of GPI codes of AAs, typical antipsychotics, and mood stabilizers/anticonvulsants. ^dAdjunctive treatment was defined as ≥ 1 antidepressant prescription dispensed in the 90-day pre-index period and ≥ 1 antidepressant prescription dispensed in the 90-day post-index period with ≥ 14 days of overlapping supply with cariprazine. ^eSee Supplemental Table 1 and 2 for list of ICD-9/10 diagnosis codes. ^fPatients with BMI analyzed also required ≥ 1 height measurement during the study period. If multiple height measurements were available, the modal value was selected; if no modal value existed, then the median value was selected. AA: atypical antipsychotic; BMI: body mass index; BP-I: bipolar I disorder; GPI: general product identifier; HCPCS: Health Care Common Procedure Coding System; ICD: International Classification of Diseases; LAI: long-acting injectable; MDD: major depressive disorder