From: Insights on the cognitive enhancement effect of desvenlafaxine in major depressive disorder
GROUPS | STATISTICS | |||
---|---|---|---|---|
MDD (n = 26) | HC (n = 40) | F or χ2 | p-value | |
Age, years | 48.8 (9.2) | 45.93 (7.6) | 1.85 | 0.178 |
Sex, n female (%) | 17 (65.4) | 22 (55) | 0.7 | 0.402 |
Years of schooling, n | 10 (3.4) | 13.18 (3.4) | 13.11 | 0.001 |
Estimated IQ, T-score | 52 (14.6) | 57.9 (8.3) | 4.44 | 0.039 |
Age at illness onset, years | 42.5 (12.1) | |||
Depressive episodes, n | 1.8 (1.1) | |||
Duration of the current episode, n | 40.6 (26.82) | |||
Baseline medication, n (%)* | ||||
Sertraline | 9 (34.6) | |||
Fluoxetine | 3 (11.5) | |||
Paroxetine | 7 (26.9) | |||
Citalopram | 5 (19.2) | |||
Escitalopram | 2 (7.7) | |||
HDRS-17, total score | 23.1 (3.3) | 2.5 (2.8) | 735.05 | < 0.001 |
CGI Severity, total score | 4.1 (0.4) | |||
RDQ, total score | 56.5 (10.9) | |||
HARS, total score | 25.1 (5.5) | 3.1 (3.5) | 369.17 | < 0.001 |
Attention/Working Memory, T-score | 42.1 (6.6) | 49.9 (10.6) | 11.27 | 0.001 |
Verbal Memory, T-score | 40.9 (8.7) | 48.1 (9.4) | 9.91 | 0.003 |
Processing Speed, T-score | 48.2 (8.4) | 53.9 (7.1) | 8.52 | 0.005 |
Executive Function, T-score | 43.4 (7 − 4) | 49.7 (5.9) | 14.30 | < 0.001 |
PDQ-D-5, total score | 12 (3.3) | 4.3 (2.4) | 114.53 | < 0.001 |
FAST, total score | 45.6 (12) | 9.2 (7.9) | 218.55 | < 0.001 |
SDS, total score | 23.6 (4.6) |