Table 2 Multivariate associations of PM2.5, PRS and MMSE score
From: The independent role of fine particulate matter and genetic liability on cognition in older adults
CP PRS | SCZ PRS | MDD PRS | AD PRS | |||||
|---|---|---|---|---|---|---|---|---|
Adjusted Beta (95% CI) a | p-value | Adjusted Beta (95% CI) a | p-value | Adjusted Beta (95% CI) a | p-value | Adjusted Beta (95% CI) a | p-value | |
PM2.5 | -0.0285 (-0.0392, -0.0178) | < 0.0001 | -0.0281 (-0.0389, -0.0174) | < 0.0001 | -0.0280 (-0.0387, -0.0172) | < 0.0001 | -0.0276 (-0.0388, -0.0168) | < 0.0001 |
PRS | 0.1729 (0.1470, 0.1988) | < 0.0001 | -0.0632 (-0.0891, -0.0374) | < 0.0001 | 0.0152 (-0.0107, 0.0410) | 0.2503 | -0.0321 (-0.0580, -0.0062) | 0.0153 |
Age | -0.0454 (-0.0531, -0.0378) | < 0.0001 | -0.0450 (-0.0527, -0.0373) | < 0.0001 | -0.0450 (-0.0527, -0.0373) | < 0.0001 | -0.0450 (-0.0527, -0.0373) | < 0.0001 |
Sex | ||||||||
Male | Ref. | Ref. | Ref. | Ref. | ||||
Female | 0.1321 (0.0766, 0.1876) | < 0.0001 | 0.1369 (0.0813, 0.1926) | < 0.0001 | 0.1358 (0.0802, 0.1915) | < 0.0001 | 0.1319 (0.0761, 0.1878) | < 0.0001 |
Education | ||||||||
Illiteracy, self-study, or elementary school | Ref. | Ref. | Ref. | Ref. | ||||
Junior high school | 1.4837 (1.3793, 1.5882) | < 0.0001 | 1.4940 (1.3893, 1.5987) | < 0.0001 | 1.4935 (1.3887, 1.5983) | < 0.0001 | 1.4902 (1.3852, 1.5952) | < 0.0001 |
Senior (Vocational) high school | 2.3692 (2.2824, 2.4560) | < 0.0001 | 2.3859 (2.2989, 2.4730) | < 0.0001 | 2.3835 (2.2964, 2.4706) | < 0.0001 | 2.3816 (2.2943, 2.4689) | < 0.0001 |
University (College) | 2.9229 (2.8346, 3.0112) | < 0.0001 | 2.9660 (2.8777, 3.0544) | < 0.0001 | 2.9613 (2.8728, 3.0497) | < 0.0001 | 2.9592 (2.8705, 3.0478) | < 0.0001 |
Master and above | 3.1418 (3.0118, 3.2717) | < 0.0001 | 3.2006 (3.0705, 3.3307) | < 0.0001 | 3.1959 (3.0658, 3.3261) | < 0.0001 | 3.1896 (3.0591, 3.3201) | < 0.0001 |
Median household income | 0.0014 (0.0004, 0.0025) | 0.0081 | 0.0015 (0.0004, 0.0025) | 0.0085 | 0.0014 (0.0004, 0.0025) | 0.0088 | 0.0014 (0.0003, 0.0025) | 0.0097 |
CV household income | 0.0001 (-0.0001, 0.0004) | 0.2716 | 0.0001 (-0.0001, 0.0004) | 0.2639 | 0.0002 (-0.0001, 0.0004) | 0.2516 | 0.0002 (-0.0001, 0.0004) | 0.2270 |
Urbanization | ||||||||
1 (Urban) | Ref. | Ref. | Ref. | Ref. | ||||
2 (Sub-urban) | -0.1725 (-0.3393, -0.0056) | 0.0428 | -0.1733 (-0.3415, -0.0051) | 0.0434 | -0.1721 (-0.3402, -0.0041) | 0.0447 | -0.1774 (-0.3458, -0.0089) | 0.0390 |
3 (Rural) | -0.1577 (-0.4642, 0.1487) | 0.3131 | -0.1636 (-0.4722, 0.1450) | 0.2987 | -0.1637 (-0.4721, 0.1447) | 0.2981 | -0.1676 (-0.4767, 0.1415) | 0.2879 |